1015 is the biggest club in the city and 20,000 square feet and 150,000 watts can make for a good party - check the schedule.
It can also be a fairly young, drunk (or more) and crowded scene... not everyone's cup of tea - in which case - the EndUp is a block away (6th and Harrison) with the main centroid of SOMA nightlife 6 blocks away at 11th st and Folsom. The DNA Lounge on 11th hosts a reliably strong lineup.
Address: 1015 Folsom, SF, CA
Website: http://1015.com/tenfifteen